Research

Chromatin, the complex of DNA and associated proteins, is essential for maintaining homeostasis regulating gene expression and other DNA-templated processes such as DNA-damage repair. Loss of this control though cancer-associated genetic alterations in chromatin regulators promotes cancer phenotypes including aberrant gene expression programs and altered differentiation states. There are myriad recurrent genetic alterations in chromatin [...]

The DNA of our genome is packaged around nucleosome particles, which are composed of histone proteins. The positioning and stability of the nucleosomes relative to specific DNA sequences, their histone subunit composition, and chemical modifications are critical to the regulation of gene expression and other DNA-templated processes. Genes encoding chromatin modifying proteins are recurrently altered [...]